Open AccessEgr1: a novel target for ameliorating acute allograft rejection in an experimental lung transplant model†
Author(s) -
Naohisa Waki,
Masaomi Yamane,
S. Yamamoto,
Mikio Okazaki,
Seiichiro Sugimoto,
Akihiro Matsukawa,
Takahiro Oto,
Shinichiro Miyoshi
Publication year - 2011
Publication title -
european journal of cardio-thoracic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 133
eISSN - 1873-734X
pISSN - 1010-7940
DOI - 10.1093/ejcts/ezr030
Subject(s) - lung transplantation , lung , transplantation , medicine , downregulation and upregulation , monocyte , immunohistochemistry , egr1 , andrology , immunology , biology , gene , biochemistry
Acute allograft rejection is one of the significant complications occurring in lung transplant recipients. Early growth response-1 (Egr-1), zinc-finger-type transcription factor, is known as a master switch regulator of diverse chemical mediators. We used an orthotopic mouse model of left lung transplant to elucidate the function of Egr-1 in acute pulmonary rejection.
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