Effects of hypobaric hypoxia exposure at high altitude on left ventricular twist in healthy subjects: data from HIGHCARE study on Mount Everest | Zendy

Giuseppe Osculati | Zendy; Miriam Revera | Zendy; Giovanna Branzi | Zendy; Andrea Faini | Zendy; Gabriella Malfatto | Zendy; Grzegorz Bilo | Zendy; Andrea Giuliano | Zendy; Francesca Gregorini | Zendy; Francesca Ciambellotti | Zendy; Carolina Lombardi | Zendy; Piergiuseppe Agostoni | Zendy; Giuseppe Mancia | Zendy; Gianfranco Parati | Zendy

Open Access

Effects of hypobaric hypoxia exposure at high altitude on left ventricular twist in healthy subjects: data from HIGHCARE study on Mount Everest

Author(s) -

Giuseppe Osculati,

Miriam Revera,

Giovanna Branzi,

Andrea Faini,

Gabriella Malfatto,

Grzegorz Bilo,

Andrea Giuliano,

Francesca Gregorini,

Francesca Ciambellotti,

Carolina Lombardi,

Piergiuseppe Agostoni,

Giuseppe Mancia,

Gianfranco Parati

Publication year - 2015

Publication title -

european heart journal - cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.576

H-Index - 92

eISSN - 2047-2412

pISSN - 2047-2404

DOI - 10.1093/ehjci/jev166

Subject(s) - ventricle , medicine , cardiology , effects of high altitude on humans , hypobaric chamber , hypoxia (environmental) , twist , diastole , contractility , angiotensin ii , blood pressure , oxygen , anatomy , chemistry , geometry , mathematics , organic chemistry

Previous studies investigating the effect of hypoxia on left ventricle focused on its global function, an approach that may not detect a selective dysfunction of subendocardial layers that are most sensitive to an inadequate oxygen supply. In the HIGHCARE study, aimed at exploring the effects of high altitude hypoxia on multiple biological variables and their modulation by an angiotensin receptor blocker, we addressed the effects of hypobaric hypoxia on both systolic and diastolic left ventricular geometry and function, focusing on echocardiographic assessment of left ventricle twist to indirectly examine subendocardial left ventricular systolic function.

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