DNA methylation alterations in Alzheimer’s disease | Zendy

Amy S. Yokoyama | Zendy; John C. Rutledge | Zendy; Valentina Medici | Zendy

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DNA methylation alterations in Alzheimer’s disease

Author(s) -

Amy S. Yokoyama,

John C. Rutledge,

Valentina Medici

Publication year - 2017

Publication title -

current zoology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 38

eISSN - 2058-5888

pISSN - 1674-5507

DOI - 10.1093/eep/dvx008

Subject(s) - epigenetics , dna methylation , biology , histone , genetics , disease , methylation , epigenomics , dna , gene , computational biology , medicine , gene expression , pathology

The observation that Alzheimer’s disease (AD) patients with similar and even identical genetic backgrounds often present with heterogeneous pathologies has prompted the hypothesis that epigenetics may contribute to AD. While the study of epigenetics encompasses a variety of modifications including histone modifications and non-coding RNAs, much of the research on how epigenetics might impact AD pathology has been focused on DNA methylation. To this end, several studies have characterized DNA methylation alterations in various brain regions of individuals with AD, with conflicting results. This review examines the results of studies analyzing both global and gene-specific DNA methylation changes in AD and also assesses the results of studies analyzing DNA hydroxymethylation in patients with AD.

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