Probing the germline-dependence of epigenetic inheritance using artificial insemination in mice | Zendy

Johannes Bohacek | Zendy; Sarah von Werdt | Zendy; Isabelle M. Mansuy | Zendy

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Probing the germline-dependence of epigenetic inheritance using artificial insemination in mice

Author(s) -

Johannes Bohacek,

Sarah von Werdt,

Isabelle M. Mansuy

Publication year - 2016

Publication title -

current zoology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 38

eISSN - 2058-5888

pISSN - 1674-5507

DOI - 10.1093/eep/dvv015

Subject(s) - germline , epigenetics , biology , offspring , inheritance (genetic algorithm) , artificial insemination , genetics , insemination , mating , pregnancy , gene

We developed a simple, noninvasive artificial insemination technique to study epigenetic germline inheritance in mice. This technique avoids interfering factors introduced by superovulation, surgery, in vitro culture or mating that can confound the transmission of acquired epigenetic information through the germline. Using a stress model, we demonstrate that our method is suited to test the causal involvement of the male germline in transmitting acquired information from father to offspring

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