The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5‐HT3 Receptor Pathway in Rats | Zendy

Kazunari Tominaga | Zendy; Toshitaka Kido | Zendy; Masahiro Ochi | Zendy; Chiharu Sadakane | Zendy; Akihito Mase | Zendy; Hirokazu Okazaki | Zendy; Hirokazu Yamagami | Zendy; Tetsuya Tanigawa | Zendy; K. Watanabe | Zendy; Toshio Watanabe | Zendy; Yasuhiro Fujiwara | Zendy; Nobuhide Oshitani | Zendy; T. Arakawa | Zendy

Open Access

The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5‐HT₃ Receptor Pathway in Rats

Author(s) -

Kazunari Tominaga,

Toshitaka Kido,

Masahiro Ochi,

Chiharu Sadakane,

Akihito Mase,

Hirokazu Okazaki,

Hirokazu Yamagami,

Tetsuya Tanigawa,

K. Watanabe,

Toshio Watanabe,

Yasuhiro Fujiwara,

Nobuhide Oshitani,

T. Arakawa

Publication year - 2009

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1093/ecam/nep173

Subject(s) - gastric emptying , pharmacology , agonist , ondansetron , chemistry , receptor antagonist , medicine , 5 ht receptor , serotonin , receptor , antagonist , endocrinology , stomach , nausea

The traditional Japanese medicine rikkunshito ameliorates the nitric oxide-associated delay in gastric emptying. Whether rikkunshito affects gastric motility associated with 5-hydroxytryptamine (serotonin: 5-HT) receptors or dopamine receptors is unknown. We examined the effects of rikkunshito on the delay in gastric emptying induced by 5-HT or dopamine using the phenol red method in male Wistar rats. 5-HT (0.01–1.0 mg kg −1 , i.p.) dose dependently delayed gastric emptying, similar to the effect of the 5-HT 3 receptor agonist 1-(3-chlorophenyl) biguanide (0.01–1.0 mg kg −1 , i.p.). Dopamine also dose dependently delayed gastric emptying. The 5-HT 3 receptor antagonist ondansetron (0.04–4.0 mg kg −1 ) and rikkunshito (125–500 mg kg −1 ) significantly suppressed the delay in gastric emptying caused by 5-HT or 1-(3-chlorophenyl) biguanide. Hesperidin (the most active ingredient in rikkunshito) suppressed the 5-HT-induced delayed gastric emptying in a dose-dependent manner, the maximum effect of which was similar to that of ondansetron (0.4 mg kg −1 ). The improvement obtained by rikkunshito or ondansetron in delaying gastric emptying was completely blocked by pretreatment with atropine. Rikkunshito appears to improve delay in gastric emptying via the antagonistic action of the 5-HT 3 receptor pathway.

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