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Infection with  Helicobacter pylori  is strongly associated with gastric cancer and gastric adenocarcinoma. WHO classified  H. pylori  as a group 1 carcinogen in 1994.  Impatiens balsamina  L. has been used as indigenous medicine in Asia for the treatment of rheumatism, fractures and fingernail inflammation. In this study, we isolated anti- H. pylori  compounds from this plant and investigated their anti- and bactericidal activity. Compounds of 2-methoxy-1,4-naphthoquinone (MeONQ) and stigmasta-7,22-diene-3  β  -ol (spinasterol) were isolated from the pods and roots/stems/leaves of  I. balsamina  L., respectively. The minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) for MeONQ were in the ranges of 0.156–0.625 and 0.313–0.625   μ  g mL −1 , respectively, and in the ranges of 20–80   μ  g mL −1  both of MICs and MBCs for spinasterol against antibiotic (clarithromycin, metronidazole and levofloxacin) resistant  H. pylori . Notably, the activity of MeONQ was equivalent to that of amoxicillin (AMX). The bactericidal  H. pylori  action of MeONQ was dose-dependent. Furthermore, the activity of MeONQ was not influenced by the environmental pH values (4–8) and demonstrated good thermal (121°C for 15 min) stability. MeONQ abounds in the  I. balsamina  L. pod at the level of 4.39% (w/w db). In conclusion, MeONQ exhibits strong potential to be developed as a candidate agent for the eradication of  H. pylori  infection.

evidence-based complementary and alternative medicine

In VitroActivity of 2-methoxy-1,4-naphthoquinone and Stigmasta-7,22-diene-3β-ol fromImpatiens balsaminaL. against Multiple Antibiotic-ResistantHelicobacter pylori