Open AccessMutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
Author(s) -
Tamara Regina Calvo,
Cássia Regina Cardoso,
Adriana Candido da Silva Moura,
Lourdes Campaner dos Santos,
Ilce Mara S. Cólus,
Wagner Vilegas,
Eliana Aparecida Varanda
Publication year - 2009
Publication title -
evidence-based complementary and alternative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.552
H-Index - 90
eISSN - 1741-4288
pISSN - 1741-427X
DOI - 10.1093/ecam/nep123
Subject(s) - flavonoid , indigo , chemistry , kaempferol , indirubin , quercetin , alkaloid , traditional medicine , botany , biology , biochemistry , stereochemistry , antioxidant , medicine , art , visual arts
Indigofera truxillensis and I. suffruticosa , are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by means of Salmonella/ microsome assays using TA100, TA98, TA102 and TA97a strains. The methanolic extract of I. truxillensis showed mutagenic activity in the TA98 strain without S9 while glycerolipid fraction was devoid of activity. The flavonoid and alkaloid fractions of both plants showed mutagenicity. Chemical analysis of flavonoid fractions of I. truxillensis and I. suffruticosa resulted in the identification of kaempferol, quercetin and their derivatives. The alkaloid fraction of both the species contained indigo and indirubin and indigo was found mainly responsible for the mutagenic activity.
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