Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity

Bioassay-guided fractionation of the chloroform extract of Byrsonima fagifolia leaves led to the isolation of active antitubercular compounds alkane dotriacontane (Minimal Inhibitory Concentration—MIC, 62.5  μ g mL −1 ), triterpenoids as bassic acid (MIC = 2.5  μ g mL −1 ), α -amyrin acetate (MIC = 62.5  μ g mL −1 ), a mixture of lupeol, α - and β -amyrin (MIC = 31.5  μ g mL −1 ) and a mixture of lupeol, and acetates of α - and β -amyrin (MIC = 31.5  μ g mL −1 ). The antimycobacterial activity was determined by the Microplate Alamar Blue Assay (MABA) and the structures of promising compounds were determined by spectroscopic analysis. This investigation constitutes the first report of a chemical and antitubercular study of apolar compounds from B. fagifolia Niedenzu (IK).