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Studies with foods high in flavonoids have demonstrated improvement in endothelial function. We investigated whether 4 weeks of flavonoid supplementation would prevent an adverse impact on endothelial function of a high-fat meal. Endothelial function was measured by reactive hyperemia peripheral arterial tonometry (RH-PAT). The RH-PAT index was measured both before and 3 h after a high-fat meal, in 23 healthy volunteers. Subjects were randomized in a double-blind, cross-over design to 4 weeks of daily supplementation with OPC-3, or a matching placebo. RH-PAT index before and after the high-fat meal was measured at the beginning and end of each 4-week treatment phase. The high-fat meal caused a decline in endothelial function at baseline in the placebo ( - 10.71%,  P  = .006) and flavonoid [ - 9.97% ( P  = .077)] groups, and there was no difference in decline between arms ( P  = .906). The high-fat meal produced a decline after 4 weeks of placebo [ - 12.37% ( P  = .005)], but no decline after 4 weeks of flavonoid supplement [ - 3.16% ( P  = .663)], and the difference between the two responses was highly significant ( P  < .0001). Within-group comparisons revealed no difference in endothelial function decline in the placebo arm between baseline and 4 weeks [ - 10.71% versus  - 12.37% ( P  = .758)]. In the flavonoid supplement arm, the difference in endothelial function decline between baseline and 4 weeks was  - 9.97% versus  - 3.16%, but did not reach statistical significance ( P  = .451). These results suggest that the flavonoid supplement used in this study mitigates the impairment of endothelial function caused by a high-fat meal. Whether certain subpopulations derive greater or lesser benefit remains unclear.

Potential Benefits on Impairment of Endothelial Function after a High-Fat Meal of 4 Weeks of Flavonoid Supplementation