Reflux esophagitis in humans is a free radical event | Zendy

Gerold J. Wetscher | Zendy; Ronald A. Hinder | Zendy; Paul J. Klingler | Zendy; Michael Gadenstätter | Zendy; Galen Perdikis | Zendy; Paul R. Hinder | Zendy

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Reflux esophagitis in humans is a free radical event

Author(s) -

Gerold J. Wetscher,

Ronald A. Hinder,

Paul J. Klingler,

Michael Gadenstätter,

Galen Perdikis,

Paul R. Hinder

Publication year - 1997

Publication title -

diseases of the esophagus

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.115

H-Index - 63

eISSN - 1442-2050

pISSN - 1120-8694

DOI - 10.1093/dote/10.1.29

Subject(s) - medicine , reflux esophagitis , esophagitis , reflux , event (particle physics) , gastroenterology , disease , physics , quantum mechanics

In this study, we investigated the implication of oxygen-derived free radicals in reflux esophagitis of humans. For this purpose we assessed oxidative stress in distal esophageal biopsies of controls, patients with various grades of esophagitis, Barrett's esophagus with and without severe associated esophagitis and patients following Nissen fundoplication. The total amount of oxygen-derived free radicals was measured by chemiluminescence. Membrane damage caused by free radicals was assessed by analysis of lipid peroxidation. In addition, we measured esophageal mucosal tissue levels of the free radical scavenger superoxide dismutase.

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