srb: a Bacillus subtilis Gene Encoding a Homologue of the -Subunit of the Mammalian Signal Recognition Particle Receptor | Zendy

Asami OguroAndo | Zendy

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srb: a Bacillus subtilis Gene Encoding a Homologue of the -Subunit of the Mammalian Signal Recognition Particle Receptor

Author(s) -

Asami OguroAndo

Publication year - 1995

Publication title -

dna research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.647

H-Index - 98

eISSN - 1756-1663

pISSN - 1340-2838

DOI - 10.1093/dnares/2.2.95

Subject(s) - bacillus subtilis , biology , signal recognition particle , signal peptide , gene , protein subunit , peptide sequence , escherichia coli , g alpha subunit , signal recognition particle receptor , microbiology and biotechnology , biochemistry , genetics , bacteria

We cloned a Bacillus subtilis gene (srb) encoding a homologue of the mammalian signal recognition particle receptor alpha-subunit (SR alpha). The gene is 987 bp in length and encodes a 329-amino acid protein. The deduced amino acid sequence of the protein shared 26.6, 36.2 and 49.7% identity with those of mammalian SR alpha, archaebacterial DP alpha and Escherichia coli FtsY, respectively. The protein contains three conserved GTP-binding elements like the other three SRP receptor proteins, though the N-terminal portion of the putative B. subtilis protein was shorter than the others. Secondary structure prediction showed than an amphipathic alpha-helix is positioned in the N-terminal region. A defect in srb inhibited cell growth and protein translocation.

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