TP53LNC-DB, the database of lncRNAs in the p53 signalling network | Zendy

Muhammad Riaz Khan | Zendy; Ihtisham Bukhari | Zendy; Ranjha Khan | Zendy; Hafiz Muhammad Jafar Hussain | Zendy; Mian Wu | Zendy; Rick F. Thorne | Zendy; Jinming Li | Zendy; Guangzhi Liu | Zendy

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TP53LNC-DB, the database of lncRNAs in the p53 signalling network

Author(s) -

Muhammad Riaz Khan,

Ihtisham Bukhari,

Ranjha Khan,

Hafiz Muhammad Jafar Hussain,

Mian Wu,

Rick F. Thorne,

Jinming Li,

Guangzhi Liu

Publication year - 2018

Publication title -

database

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.406

H-Index - 62

ISSN - 1758-0463

DOI - 10.1093/database/bay136

Subject(s) - signalling , senescence , cell cycle checkpoint , transcription factor , genome , gene , computational biology , transcription (linguistics) , biology , computer science , cell cycle , genetics , microbiology and biotechnology , linguistics , philosophy

The TP53 gene product, p53, is a pleiotropic transcription factor induced by stress, which functions to promote cell cycle arrest, apoptosis and senescence. Genome-wide profiling has revealed an extensive system of long noncoding RNAs (lncRNAs) that is integral to the p53 signalling network. As a research tool, we implemented a public access database called TP53LNC-DB that annotates currently available information relating lncRNAs to p53 signalling in humans.

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