The integrated National NeuroAIDS Tissue Consortium database: a rich platform for neuroHIV research | Zendy

Abigail J. Heithoff | Zendy; Steven Totusek | Zendy; Manh Duc Le | Zendy; Lucas Barwick | Zendy; Gary Gensler | Zendy; Donald Franklin | Zendy; Allison C Dye | Zendy; Sanjit Pandey | Zendy; Seth Sherman | Zendy; Chittibabu Guda | Zendy; Howard S. Fox | Zendy

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The integrated National NeuroAIDS Tissue Consortium database: a rich platform for neuroHIV research

Author(s) -

Abigail J. Heithoff,

Steven Totusek,

Manh Duc Le,

Lucas Barwick,

Gary Gensler,

Donald Franklin,

Allison C Dye,

Sanjit Pandey,

Seth Sherman,

Chittibabu Guda,

Howard S. Fox

Publication year - 2018

Publication title -

database

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.406

H-Index - 62

ISSN - 1758-0463

DOI - 10.1093/database/bay134

Subject(s) - computer science , database , human immunodeficiency virus (hiv) , data access , data integration , research data , data science , ontology , information retrieval , medicine , data curation , family medicine , philosophy , epistemology

Herein we present major updates to the National NeuroAIDS Tissue Consortium (NNTC) database. The NNTC's ongoing multisite clinical research study was established to facilitate access to ante-mortem and post-mortem data, tissues and biofluids for the neurohuman immunodeficiency virus (HIV) research community. Recently, the NNTC has expanded to include data from the central nervous system HIV Antiretroviral Therapy Effects Research (CHARTER) study. The data and biospecimens from CHARTER and NNTC cohorts are available to qualified researchers upon request. Data generated by requestors using NNTC biospecimens and tissues are returned to the NNTC upon the conclusion of requestors' work, and this external, experimental data are annotated and curated in the publically accessible NNTC database, thereby extending the utility of each case. A flexible and extensible database ontology allows the integration of disparate data sets, including external experimental data, clinical neuropsychological and neuromedical testing data, tissue pathology and neuroimaging data.

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