PepPSy: a web server to prioritize gene products in experimental and biocuration workflows | Zendy

Olivier Sallou | Zendy; Paula Duek | Zendy; Thomas Darde | Zendy; Olivier Collin | Zendy; Lydie Lane | Zendy; Frédéric Chalmel | Zendy

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PepPSy: a web server to prioritize gene products in experimental and biocuration workflows

Author(s) -

Olivier Sallou,

Paula Duek,

Thomas Darde,

Olivier Collin,

Lydie Lane,

Frédéric Chalmel

Publication year - 2016

Publication title -

database

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.406

H-Index - 62

ISSN - 1758-0463

DOI - 10.1093/database/baw070

Subject(s) - annotation , workflow , computer science , prioritization , gene , world wide web , computational biology , human genome , web server , genome , information retrieval , biology , the internet , genetics , database , artificial intelligence , management science , economics

Among the 20 000 human gene products predicted from genome annotation, about 3000 still lack validation at protein level. We developed PepPSy, a user-friendly gene expression-based prioritization system, to help investigators to determine in which human tissues they should look for an unseen protein. PepPSy can also be used by biocurators to revisit the annotation of specific categories of proteins based on the 'omics' data housed by the system. In this study, it was used to prioritize 21 dubious protein-coding genes among the 616 annotated in neXtProt for reannotation. PepPSy is freely available at http://peppsy.genouest.orgDatabase URL: http://peppsy.genouest.org.

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