FlyVar: a database for genetic variation in Drosophila melanogaster | Zendy

Fei Wang | Zendy; Lichun Jiang | Zendy; Yong Chen | Zendy; Nele A. Haelterman | Zendy; Hugo J. Bellen | Zendy; Rui Chen | Zendy

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FlyVar: a database for genetic variation in Drosophila melanogaster

Author(s) -

Fei Wang,

Lichun Jiang,

Yong Chen,

Nele A. Haelterman,

Hugo J. Bellen,

Rui Chen

Publication year - 2015

Publication title -

database

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.406

H-Index - 62

ISSN - 1758-0463

DOI - 10.1093/database/bav079

Subject(s) - drosophila melanogaster , annotation , genome , melanogaster , computer science , dna sequencing , shotgun sequencing , computational biology , genomics , graphical user interface , biology , database , genetics , gene , programming language

FlyVar is a publicly and freely available platform that addresses the increasing need of next generation sequencing data analysis in the Drosophila research community. It is composed of three parts. First, a database that contains 5.94 million DNA polymorphisms found in Drosophila melanogaster derived from whole genome shotgun sequencing of 612 genomes of D. melanogaster. In addition, a list of 1094 dispensable genes has been identified. Second, a graphical user interface (GUI) has been implemented to allow easy and flexible queries of the database. Third, a set of interactive online tools enables filtering and annotation of genomic sequences obtained from individual D. melanogaster strains to identify candidate mutations. FlyVar permits the analysis of next generation sequencing data without the need of extensive computational training or resources. Database URL: www.iipl.fudan.edu.cn/FlyVar.

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