ParkDB: a Parkinson's disease gene expression database | Zendy

Cristian Taccioli | Zendy; Valeria Maselli | Zendy; Jesper Tegnér | Zendy; David Gómez-Cabrero | Zendy; Gioia Altobelli | Zendy; Warren Emmett | Zendy; Francesco Lescai | Zendy; Stefano Gustincich | Zendy; Elia Stupka | Zendy

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ParkDB: a Parkinson's disease gene expression database

Author(s) -

Cristian Taccioli,

Valeria Maselli,

Jesper Tegnér,

David Gómez-Cabrero,

Gioia Altobelli,

Warren Emmett,

Francesco Lescai,

Stefano Gustincich,

Elia Stupka

Publication year - 2011

Publication title -

database

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.406

H-Index - 62

ISSN - 1758-0463

DOI - 10.1093/database/bar007

Subject(s) - substantia nigra , neurodegeneration , dopaminergic , parkinson's disease , disease , neuroscience , gene expression , database , gene , biology , bioinformatics , computational biology , computer science , medicine , dopamine , pathology , genetics

Parkinson's disease (PD) is a common, adult-onset, neuro-degenerative disorder characterized by the degeneration of cardinal motor signs mainly due to the loss of dopaminergic neurons in the substantia nigra. To date, researchers still have limited understanding of the key molecular events that provoke neurodegeneration in this disease. Here, we present ParkDB, the first queryable database dedicated to gene expression in PD. ParkDB contains a complete set of re-analyzed, curated and annotated microarray datasets. This resource enables scientists to identify and compare expression signatures involved in PD and dopaminergic neuron differentiation under different biological conditions and across species

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