NADPH oxidase-4 promotes eccentric cardiac hypertrophy in response to volume overload | Zendy

Moritz Schnelle | Zendy; Iain A. Sawyer | Zendy; Narayana Anilkumar | Zendy; Belal A. Mohamed | Zendy; Daniel A. Richards | Zendy; Karl Toischer | Zendy; Min Zhang | Zendy; Norman Catibog | Zendy; Greta J. Sawyer | Zendy; Héloïse MongueDin | Zendy; Katrin Schröder | Zendy; Gerd Hasenfuß | Zendy; Ajay M. Shah | Zendy

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NADPH oxidase-4 promotes eccentric cardiac hypertrophy in response to volume overload

Author(s) -

Moritz Schnelle,

Iain A. Sawyer,

Narayana Anilkumar,

Belal A. Mohamed,

Daniel A. Richards,

Karl Toischer,

Min Zhang,

Norman Catibog,

Greta J. Sawyer,

Héloïse MongueDin,

Katrin Schröder,

Gerd Hasenfuß,

Ajay M. Shah

Publication year - 2019

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvz331

Subject(s) - nox4 , pressure overload , medicine , endocrinology , volume overload , nadph oxidase , ventricular remodeling , muscle hypertrophy , protein kinase b , eccentric , fibrosis , stroke volume , heart failure , ejection fraction , cardiology , biology , phosphorylation , chemistry , microbiology and biotechnology , oxidative stress , cardiac hypertrophy , physics , quantum mechanics

Chronic pressure or volume overload induce concentric vs. eccentric left ventricular (LV) remodelling, respectively. Previous studies suggest that distinct signalling pathways are involved in these responses. NADPH oxidase-4 (Nox4) is a reactive oxygen species-generating enzyme that can limit detrimental cardiac remodelling in response to pressure overload. This study aimed to assess its role in volume overload-induced remodelling.

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