A thioredoxin-mimetic peptide exerts potent anti-inflammatory, antioxidant, and atheroprotective effects in ApoE2.Ki mice fed high fat diet | Zendy

Fanny Canesi | Zendy; Véronique Mateo | Zendy; Dominique Couchie | Zendy; Sonia Karabina | Zendy; Anne NègreSalvayre | Zendy; Mustapha Rouis | Zendy; Khadija El Hadri | Zendy

Open Access

A thioredoxin-mimetic peptide exerts potent anti-inflammatory, antioxidant, and atheroprotective effects in ApoE2.Ki mice fed high fat diet

Author(s) -

Fanny Canesi,

Véronique Mateo,

Dominique Couchie,

Sonia Karabina,

Anne NègreSalvayre,

Mustapha Rouis,

Khadija El Hadri

Publication year - 2018

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvy183

Subject(s) - inflammation , oxidative stress , tumor necrosis factor alpha , endocrinology , chemistry , proinflammatory cytokine , medicine , thioredoxin , reactive oxygen species , adiponectin , pharmacology , biology , biochemistry , insulin resistance , insulin

Oxidative stress and inflammation play a pathogenic role in atherosclerosis. Thioredoxin-1 (Trx-1) is an anti-oxidative, anti-inflammatory protein with atheroprotective effects. However, in vivo cleavage of Trx-1 generates a truncated pro-inflammatory protein, Trx-80, which compromises the therapeutic use of Trx-1. Here we analysed whether the thioredoxin-mimetic peptide (TxMP), CB3 might exert anti-oxidative, anti-inflammatory, and atheroprotective effects in ApoE2.Ki mice.

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