Open AccessCritical role of histone demethylase Jumonji domain-containing protein 3 in the regulation of neointima formation following vascular injury
Author(s) -
Xiaoling Luo,
Di Yang,
Weijun Wu,
Fen Long,
Chenxi Xiao,
Ming Qin,
Betty Yuen Kwan Law,
Rinkiko Suguro,
Xin Xu,
Lefeng Qu,
Xinhua Liu,
Yi Zhun Zhu
Publication year - 2018
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvy176
Subject(s) - neointima , demethylase , histone , microbiology and biotechnology , chemistry , biochemistry , medicine , biology , restenosis , dna , stent
Jumonji domain-containing protein 3 (JMJD3), also called lysine specific demethylase 6B (KDM6b), is an inducible histone demethylase which plays an important role in many biological processes, however, its function in vascular remodelling remains unknown. We aim to demonstrate that JMJD3 mediates vascular neointimal hyperplasia following carotid injury, and proliferation and migration in platelet-derived growth factor BB (PDGF-BB)-induced vascular smooth muscle cells (VSMCs).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom