PDE4 and mAKAPβ are nodal organizers of β2-ARs nuclear PKA signalling in cardiac myocytes | Zendy

Ibrahim Bedioune | Zendy; Florence Lefebvre | Zendy; Patrick Lechène | Zendy; Audrey Varin | Zendy; Valérie Domergue | Zendy; Michael S. Kapiloff | Zendy; Rodolphe Fischmeister | Zendy; Grégoire Vandecasteele | Zendy

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PDE4 and mAKAPβ are nodal organizers of β2-ARs nuclear PKA signalling in cardiac myocytes

Author(s) -

Ibrahim Bedioune,

Florence Lefebvre,

Patrick Lechène,

Audrey Varin,

Valérie Domergue,

Michael S. Kapiloff,

Rodolphe Fischmeister,

Grégoire Vandecasteele

Publication year - 2018

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvy110

Subject(s) - myocyte , nodal , signalling , microbiology and biotechnology , medicine , cardiology , chemistry , endocrinology , biology

β1- and β2-adrenergic receptors (β-ARs) produce different acute contractile effects on the heart partly because they impact on different cytosolic pools of cAMP-dependent protein kinase (PKA). They also exert different effects on gene expression but the underlying mechanisms remain unknown. The aim of this study was to understand the mechanisms by which β1- and β2-ARs regulate nuclear PKA activity in cardiomyocytes.

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