Maternal diet-induced obesity programmes cardiac dysfunction in male mice independently of post-weaning diet | Zendy

Elena Loche | Zendy; Heather L. Blackmore | Zendy; Asha A. M. Carpenter | Zendy; Jessica H. Beeson | Zendy; Adele Pinnock | Zendy; Thomas J. Ashmore | Zendy; Catherine Aiken | Zendy; Juliana de Almeida-Faria | Zendy; Josca M. Schoonejans | Zendy; Dino A. Giussani | Zendy; Denise S. FernandezTwinn | Zendy; Susan E. Ozanne | Zendy

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Maternal diet-induced obesity programmes cardiac dysfunction in male mice independently of post-weaning diet

Author(s) -

Elena Loche,

Heather L. Blackmore,

Asha A. M. Carpenter,

Jessica H. Beeson,

Adele Pinnock,

Thomas J. Ashmore,

Catherine Aiken,

Juliana de Almeida-Faria,

Josca M. Schoonejans,

Dino A. Giussani,

Denise S. FernandezTwinn,

Susan E. Ozanne

Publication year - 2018

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvy082

Subject(s) - offspring , medicine , endocrinology , obesity , weaning , cardiac function curve , pregnancy , leptin , biology , heart failure , genetics

Obesity during pregnancy increases risk of cardiovascular disease (CVD) in the offspring and individuals exposed to over-nutrition during fetal life are likely to be exposed to a calorie-rich environment postnatally. Here, we established the consequences of combined exposure to a maternal and post-weaning obesogenic diet on offspring cardiac structure and function using an established mouse model of maternal diet-induced obesity.

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