Critical role of phosphodiesterase 2A in mouse congenital heart defects | Zendy

Maria Rita Assenza | Zendy; Federica Barbagallo | Zendy; Florencia Barrios | Zendy; Marisa Cornacchione | Zendy; Federica Campolo | Zendy; E. Vivarelli | Zendy; Daniele Gianfrilli | Zendy; Luigi Auletta | Zendy; Andrea Soricelli | Zendy; Andrea M. Isidori | Zendy; Andrea Lenzi | Zendy; Manuela Pellegrini | Zendy; Fabio Naro | Zendy

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Critical role of phosphodiesterase 2A in mouse congenital heart defects

Author(s) -

Maria Rita Assenza,

Federica Barbagallo,

Florencia Barrios,

Marisa Cornacchione,

Federica Campolo,

E. Vivarelli,

Daniele Gianfrilli,

Luigi Auletta,

Andrea Soricelli,

Andrea M. Isidori,

Andrea Lenzi,

Manuela Pellegrini,

Fabio Naro

Publication year - 2018

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvy030

Subject(s) - phosphodiesterase , medicine , cardiology , endocrinology , biology , enzyme , biochemistry

Phosphodiesterase 2 A (Pde2A), a cAMP-hydrolysing enzyme, is essential for mouse development; however, the cause of Pde2A knockout embryonic lethality is unknown. To understand whether Pde2A plays a role in cardiac development, hearts of Pde2A deficient embryos were analysed at different stage of development.

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