Open AccessIntegrated transcriptomic and regulatory network analyses identify microRNA-200c as a novel repressor of human pluripotent stem cell-derived cardiomyocyte differentiation and maturation
Author(s) -
Ellen Poon,
Baixia Hao,
Daogang Guan,
Mulin Jun Li,
Jun Lu,
Yong Yang,
Binbin Wu,
Stanley Chun-ming Wu,
Sarah E. Webb,
Yan Liang,
Andrew L. Miller,
Xiaoqiang Yao,
Junwen Wang,
Bin Yan,
Kenneth R. Boheler
Publication year - 2018
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvy019
Subject(s) - microrna , gene knockdown , biology , induced pluripotent stem cell , transcription factor , gene regulatory network , embryonic stem cell , gata4 , transcriptome , microbiology and biotechnology , untranslated region , regulation of gene expression , heart development , gene , gene expression , computational biology , genetics , messenger rna
MicroRNAs (miRNAs) are crucial for the post-transcriptional control of protein-encoding genes and together with transcription factors (TFs) regulate gene expression; however, the regulatory activities of miRNAs during cardiac development are only partially understood. In this study, we tested the hypothesis that integrative computational approaches could identify miRNAs that experimentally could be shown to regulate cardiomyogenesis.
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