Endogenous Sonic Hedgehog limits inflammation and angiogenesis in the ischaemic skeletal muscle of mice | Zendy

Caroline Caradu | Zendy; Alexandre Guy | Zendy; Chloé James | Zendy; Annabel Reynaud | Zendy; AlainPierre Gadeau | Zendy; MarieAnge Renault | Zendy

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Endogenous Sonic Hedgehog limits inflammation and angiogenesis in the ischaemic skeletal muscle of mice

Author(s) -

Caroline Caradu,

Alexandre Guy,

Chloé James,

Annabel Reynaud,

AlainPierre Gadeau,

MarieAnge Renault

Publication year - 2018

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvy017

Subject(s) - angiogenesis , sonic hedgehog , myogenesis , myod , endocrinology , medicine , smoothened , skeletal muscle , hedgehog , myocyte , hedgehog signaling pathway , endogeny , biology , microbiology and biotechnology , signal transduction

Hedgehog (Hh) signalling has been shown to be re-activated in ischaemic tissues and participate in ischaemia-induced angiogenesis. Sonic Hedgehog (Shh) is upregulated by more than 80-fold in the ischaemic skeletal muscle, however its specific role in ischaemia-induced angiogenesis has not yet been fully investigated. The purpose of the present study was to investigate the role of endogenous Shh in ischaemia-induced angiogenesis.

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