Open AccessInvestigation of cardiac fibroblasts using myocardial slices
Author(s) -
Filippo Perbellini,
Samuel Watson,
Martina Scigliano,
Samha Alayoubi,
S I Tkach,
Ifigeneia Bardi,
Nicholas M. Quaife,
Christopher Kane,
Neil Dufton,
A. Simón,
Markus B. Sikkel,
Giuseppe Faggian,
Anna M. Randi,
Julia Gorelik,
Siân E. Harding,
Cesare M. Terracciano
Publication year - 2017
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvx152
Subject(s) - cardiac fibrosis , myocardial fibrosis , in vitro , sma* , stimulation , medicine , angiotensin ii , endocrinology , fibrosis , biology , chemistry , cardiology , biochemistry , combinatorics , mathematics , blood pressure
Cardiac fibroblasts (CFs) are considered the principal regulators of cardiac fibrosis. Factors that influence CF activity are difficult to determine. When isolated and cultured in vitro, CFs undergo rapid phenotypic changes including increased expression of α-SMA. Here we describe a new model to study CFs and their response to pharmacological and mechanical stimuli using in vitro cultured mouse, dog and human myocardial slices.
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