Sensory innervation of perivascular adipose tissue: a crucial role in artery vasodilatation and leptin release | Zendy

Hamidah Abu Bakar | Zendy; William Dunn | Zendy; C.J. Daly | Zendy; Vera Ralevic | Zendy

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Sensory innervation of perivascular adipose tissue: a crucial role in artery vasodilatation and leptin release

Author(s) -

Hamidah Abu Bakar,

William Dunn,

C.J. Daly,

Vera Ralevic

Publication year - 2017

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvx062

Subject(s) - mesenteric arteries , endocrinology , medicine , adipokine , calcitonin gene related peptide , adipose tissue , leptin , electrical impedance myography , ghrelin , vasodilation , anatomy , chemistry , neuropeptide , artery , hormone , receptor , obesity

Electrical field stimulation (EFS) elicits robust sensory neurogenic relaxation responses in the rat isolated mesenteric arterial bed but these responses are absent or difficult to demonstrate in isolated arteries. We believe that this mismatch is due to the absence of perivascular adipose tissue (PVAT) as it is conventionally removed in studies on isolated vessels. We aimed to determine whether sensory nerves are expressed in PVAT, their physiological roles and their possible interactions with PVAT-derived adipokines.

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