Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D | Zendy

Shemsi Demolli | Zendy; Anuradha Doddaballapur | Zendy; Kavi Devraj | Zendy; Konstantin Stark | Zendy; Yosif Manavski | Zendy; Annekathrin Eckart | Zendy; Christoph M. Zehendner | Zendy; Tina Lucas | Zendy; Thomas Korff | Zendy; Markus Hecker | Zendy; Steffen Maßberg | Zendy; Stefan Liebner | Zendy; David Kaluza | Zendy; Reinier A. Boon | Zendy; Stefanie Dimmeler | Zendy

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Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D

Author(s) -

Shemsi Demolli,

Anuradha Doddaballapur,

Kavi Devraj,

Konstantin Stark,

Yosif Manavski,

Annekathrin Eckart,

Christoph M. Zehendner,

Tina Lucas,

Thomas Korff,

Markus Hecker,

Steffen Maßberg,

Stefan Liebner,

David Kaluza,

Reinier A. Boon,

Stefanie Dimmeler

Publication year - 2017

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvx032

Subject(s) - pericyte , microbiology and biotechnology , mural cell , biology , microrna , downregulation and upregulation , in vitro , endothelial stem cell , chemistry , gene , genetics

Vessel maturation involves the recruitment of mural cells such as pericytes and smooth muscle cells. Laminar shear stress is a major trigger for vessel maturation, but the molecular mechanisms by which shear stress affects recruitment of pericytes are unclear. MicroRNAs (miRs) are small non-coding RNAs, which post-transcriptionally control gene expression. The aim of the present study was to unveil the mechanism by which shear stress-regulated microRNAs contribute to vessel maturation.

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