Open AccessLong non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy
Author(s) -
Zhan-Peng Huang,
Yan Ding,
Jinghai Chen,
Gengze Wu,
Masaharu Kataoka,
Yongwu Hu,
Jian-Hua Yang,
Jianming Liu,
Stavros G. Drakos,
Craig H. Selzman,
Ján Kyselovič,
LiangHu Qu,
Cristobal G. dos Remedios,
William T. Pu,
DaZhi Wang
Publication year - 2016
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvw201
Subject(s) - biology , long non coding rna , transcriptome , gene , gene expression , extracellular matrix , microrna , microbiology and biotechnology , genetics , rna , computational biology
Ischemic cardiomyopathy (ICM) resulting from myocardial infarction is a major cause of heart failure (HF). Recently, thousands of long non-coding RNAs (lncRNAs) have been discovered and implicated in a variety of biological processes. However, the role of most lncRNAs in HF remains largely unknown. The aim of this study is to test the hypothesis that the expression and function of lncRNAs are differentially regulated in diseased hearts.
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