Augmentation of phosphate-induced osteo-/chondrogenic transformation of vascular smooth muscle cells by homoarginine | Zendy

Ioana Alesutan | Zendy; Martina Feger | Zendy; Rashad Tuffaha | Zendy; Tatsiana Castor | Zendy; Katharina Musculus | Zendy; Salvatore S. Buehling | Zendy; Christian L. Heine | Zendy; Makoto Kuroo | Zendy; Burkert Pieske | Zendy; Kurt Schmidt | Zendy; Andreas Tomaschitz | Zendy; Winfried Maerz | Zendy; Stefan Pilz | Zendy; Andreas Meinitzer | Zendy; Jakob Voelkl | Zendy; Florian Läng | Zendy

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Augmentation of phosphate-induced osteo-/chondrogenic transformation of vascular smooth muscle cells by homoarginine

Author(s) -

Ioana Alesutan,

Martina Feger,

Rashad Tuffaha,

Tatsiana Castor,

Katharina Musculus,

Salvatore S. Buehling,

Christian L. Heine,

Makoto Kuroo,

Burkert Pieske,

Kurt Schmidt,

Andreas Tomaschitz,

Winfried Maerz,

Stefan Pilz,

Andreas Meinitzer,

Jakob Voelkl,

Florian Läng

Publication year - 2016

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvw062

Subject(s) - medicine , endocrinology , vascular smooth muscle , calcification , osteopontin , asymmetric dimethylarginine , chemistry , hyperphosphatemia , arginine , biology , biochemistry , amino acid , kidney disease , smooth muscle

Reduced homoarginine plasma levels are associated with unfavourable cardiovascular outcome in chronic kidney disease (CKD). Cardiovascular events in CKD are fostered by vascular calcification, an active process promoted by hyperphosphatemia and involving osteo-/chondrogenic transformation of vascular smooth muscle cells (VSMCs). The present study explored the effect of homoarginine on phosphate-induced osteo-/chondrogenic signalling and vascular calcification.

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