Open AccessKcne2deletion attenuates acute post-ischaemia/reperfusion myocardial infarction
Author(s) -
Zhaoyang Hu,
Shawn M. Crump,
Ping Zhang,
Geoffrey W. Abbott
Publication year - 2016
Publication title -
cardiovascular research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvw048
Subject(s) - medicine , cardiology , myocardial infarction , myocardial reperfusion injury , reperfusion therapy , reperfusion injury , ischemia , infarction
Most cardiac arrhythmia-associated genes encode ion channel subunits and regulatory proteins that are also expressed outside the heart, suggesting that diseases linked to their disruption may be multifactorial. KCNE2 is a ubiquitously expressed potassium channel β subunit associated with cardiac arrhythmia, atherosclerosis, and myocardial infarction (MI) in human populations. Here, we tested the hypothesis that Kcne2 disruption in mice would influence the acute outcome of experimentally induced MI.
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