Open AccessStable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol
Author(s) -
Salam A. Ibrahim,
Suryanarayan Somanathan,
Jeffrey T. Billheimer,
James M. Wilson,
Daniel J. Rader
Publication year - 2016
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvw010
Subject(s) - ldl receptor , humanized mouse , ubiquitin ligase , endocrinology , cholesterol , medicine , lipoprotein , ubiquitin , familial hypercholesterolemia , apolipoprotein b , low density lipoprotein , receptor , chemistry , biology , pharmacology , biochemistry , immunology , gene , immune system
IDOL (inducible degrader of the low-density lipoprotein receptor, LDLR) is an E3 ubiquitin ligase that promotes the ubiquitination and degradation of the LDLR. IDOL is a potential therapeutic target for the development of a novel class of low-density lipoprotein cholesterol (LDL-C)-lowering therapies. In an attempt to develop a mouse model for testing IDOL inhibitors, we examined the effects of adeno-associated virus (AAV)-mediated stable expression of human IDOL in the livers of mice 'humanized' with regard to lipoprotein metabolism.
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