Open AccessL-type Cav1.3 channels regulate ryanodine receptor-dependent Ca2+release during sino-atrial node pacemaker activity
Author(s) -
Angelo G. Torrente,
Pietro Mesirca,
Patricia Ñeco,
Riccardo Rizzetto,
Stefan Dübel,
Christian Barrère,
Martina Sinegger-Brauns,
Jörg Striessnig,
Sylvain Richard,
Joël Nargeot,
Ana M. Gómez,
Matteo E. Mangoni
Publication year - 2016
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvw006
Subject(s) - ryanodine receptor , sinoatrial node , chemistry , medicine , receptor , endocrinology , biology , heart rate , blood pressure
Sino-atrial node (SAN) automaticity is an essential mechanism of heart rate generation that is still not completely understood. Recent studies highlighted the importance of intracellular Ca(2+) ([Ca(2+)]i) dynamics during SAN pacemaker activity. Nevertheless, the functional role of voltage-dependent L-type Ca(2+) channels in controlling SAN [Ca(2+)]i release is largely unexplored. Since Cav1.3 is the predominant L-type Ca(2+) channel isoform in SAN cells, we studied [Ca(2+)]i dynamics in isolated cells and ex vivo SAN preparations explanted from wild-type (WT) and Cav1.3 knockout (KO) mice (Cav1.3(-/-)).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom