Open AccessBidirectional cross-regulation between ErbB2 and β-adrenergic signalling pathways
Author(s) -
Polina SysaShah,
Carlo G. Tocchetti,
Manveen K. Gupta,
Peter P. Rainer,
Xiaoxu Shen,
Byunghak Kang,
Frances Belmonte,
Jian Li,
Xu Yi,
Xin Guo,
Djahida Bedja,
Wei Dong Gao,
Nazareno Paolocci,
Rutwik Rath,
Douglas B. Sawyer,
Sathyamangla V. Naga Prasad,
Kathleen L. Gabrielson
Publication year - 2015
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvv274
Subject(s) - adrenergic , signalling pathways , signalling , signal transduction , medicine , neuroscience , microbiology and biotechnology , biology , receptor
Despite the observation that ErbB2 regulates sensitivity of the heart to doxorubicin or ErbB2-targeted cancer therapies, mechanisms that regulate ErbB2 expression and activity have not been studied. Since isoproterenol up-regulates ErbB2 in kidney and salivary glands and β2AR and ErbB2 complex in brain and heart, we hypothesized that β-adrenergic receptors (AR) modulate ErbB2 signalling status.
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