Neural crest-derived resident cardiac cells contribute to the restoration of adrenergic function of transplanted heart in rodent | Zendy

Yuichi Tamura | Zendy; Motoaki Sano | Zendy; Hiroshi Nakamura | Zendy; Kentaro Ito | Zendy; Yusuke Sato | Zendy; Ken Shinmura | Zendy; Masaki Ieda | Zendy; Jun Fujita | Zendy; Hiroyuki Kurosawa | Zendy; Satohi Ogawa | Zendy; Shintaro Nakano | Zendy; Masunori Matsuzaki | Zendy; Keiichi Fukuda | Zendy

Open Access

Neural crest-derived resident cardiac cells contribute to the restoration of adrenergic function of transplanted heart in rodent

Author(s) -

Yuichi Tamura,

Motoaki Sano,

Hiroshi Nakamura,

Kentaro Ito,

Yusuke Sato,

Ken Shinmura,

Masaki Ieda,

Jun Fujita,

Hiroyuki Kurosawa,

Satohi Ogawa,

Shintaro Nakano,

Masunori Matsuzaki,

Keiichi Fukuda

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv267

Subject(s) - neural crest , cardiac function curve , rodent model , adrenergic , medicine , rodent , cardiology , biology , neuroscience , heart failure , microbiology and biotechnology , receptor , embryo , ecology

We investigated whether neural crest-derived cardiac resident cells contribute to the restoration of intrinsic adrenergic function following transplantation in mice. Transplanted heart shows partial restoration of cardiac adrenergic activity with time. Both the intrinsic cardiac adrenergic system and extrinsic sympathetic re-innervation contribute to neuronal remodelling in the transplanted heart. Little is known about the origin and function of the intrinsic system in the transplanted heart.

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