Impaired Hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy: implication in diabetes | Zendy

Candice Chapouly | Zendy; Qinyu Yao | Zendy; Soizic Vandierdonck | Zendy; Frédéric Larrieu-Lahargue | Zendy; John N. Mariani | Zendy; AlainPierre Gadeau | Zendy; MarieAnge Renault | Zendy

Open Access

Impaired Hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy: implication in diabetes

Author(s) -

Candice Chapouly,

Qinyu Yao,

Soizic Vandierdonck,

Frédéric Larrieu-Lahargue,

John N. Mariani,

AlainPierre Gadeau,

MarieAnge Renault

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv263

Subject(s) - endocrinology , medicine , hedgehog signaling pathway , smoothened , vascular permeability , endothelial dysfunction , diabetes mellitus , diabetic neuropathy , biology , signal transduction , microbiology and biotechnology

Microangiopathy, i.e. endothelial dysfunction, has long been suggested to contribute to the development of diabetic neuropathy, although this has never been fully verified. In the present paper, we have identified the role of Hedgehog (Hh) signalling in endoneurial microvessel integrity and evaluated the impact of impaired Hh signalling in endothelial cells (ECs) on nerve function.

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