Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells | Zendy

Tatsuro Minami | Zendy; Kimio Satoh | Zendy; Masamichi Nogi | Zendy; Shun Kudo | Zendy; Satoshi Miyata | Zendy; Shin-ichi Tanaka | Zendy; Hiroaki Shimokawa | Zendy

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Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells

Author(s) -

Tatsuro Minami,

Kimio Satoh,

Masamichi Nogi,

Shun Kudo,

Satoshi Miyata,

Shin-ichi Tanaka,

Hiroaki Shimokawa

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv253

Subject(s) - atorvastatin , pravastatin , protein kinase b , akt1 , rac1 , phosphorylation , microbiology and biotechnology , downregulation and upregulation , medicine , rottlerin , pharmacology , signal transduction , chemistry , biology , biochemistry , cholesterol , protein kinase a , gene

The pleiotropic effects of HMG-CoA reductase inhibitors (statins) independent of cholesterol-lowering effects have attracted much attention. We have recently demonstrated that the pleiotropic effects of statins are partly mediated through up-regulation of small GTP-binding protein dissociation stimulator (SmgGDS) with a resultant Rac1 degradation and reduced oxidative stress. However, it remains to be elucidated what molecular mechanisms are involved.

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