Translational failure of anti-inflammatory compounds for myocardial infarction: a meta-analysis of large animal models | Zendy

Gerardus P. J. van Hout | Zendy; Sanne J. Jansen of Lorkeers | Zendy; Kimberley E. Wever | Zendy; Emily S. Sena | Zendy; Lisanne H. J. A. Kouwenberg | Zendy; Wouter W. van Solinge | Zendy; Malcolm Macleod | Zendy; Pieter A. Doevendans | Zendy; Gerard Pasterkamp | Zendy; Steven A.J. Chamuleau | Zendy; Imo E. Hoefer | Zendy

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Translational failure of anti-inflammatory compounds for myocardial infarction: a meta-analysis of large animal models

Author(s) -

Gerardus P. J. van Hout,

Sanne J. Jansen of Lorkeers,

Kimberley E. Wever,

Emily S. Sena,

Lisanne H. J. A. Kouwenberg,

Wouter W. van Solinge,

Malcolm Macleod,

Pieter A. Doevendans,

Gerard Pasterkamp,

Steven A.J. Chamuleau,

Imo E. Hoefer

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv239

Subject(s) - medicine , myocardial infarction , confidence interval , heart failure , animal studies , meta analysis , cardiology

Numerous anti-inflammatory drugs have been tested in large animal studies of myocardial infarction (MI). Despite positive results, translation of anti-inflammatory strategies into clinical practice has proved to be difficult. Critical disparities between preclinical and clinical study design that influence efficacy may partly be responsible for this translational failure. The aim of the present systematic review was to better understand which factors underlie the failure of transition towards the clinic.

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