Nanotherapeutics for inhibition of atherogenesis and modulation of inflammation in atherosclerotic plaques | Zendy

Daniel R. Lewis | Zendy; Latrisha K. Petersen | Zendy; Adam W. York | Zendy; Sonali Ahuja | Zendy; Hoonbyung Chae | Zendy; Laurie B. Joseph | Zendy; Saum Rahimi | Zendy; Kathryn E. Uhrich | Zendy; Paul B. Haser | Zendy; Prabhas V. Moghe | Zendy

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Nanotherapeutics for inhibition of atherogenesis and modulation of inflammation in atherosclerotic plaques

Author(s) -

Daniel R. Lewis,

Latrisha K. Petersen,

Adam W. York,

Sonali Ahuja,

Hoonbyung Chae,

Laurie B. Joseph,

Saum Rahimi,

Kathryn E. Uhrich,

Paul B. Haser,

Prabhas V. Moghe

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv237

Subject(s) - inflammation , arteriosclerosis , medicine , chemistry , cardiology

Atherosclerotic development is exacerbated by two coupled pathophysiological phenomena in plaque-resident cells: modified lipid trafficking and inflammation. To address this therapeutic challenge, we designed and investigated the efficacy in vitro and ex vivo of a novel 'composite' nanotherapeutic formulation with dual activity, wherein the nanoparticle core comprises the antioxidant α-tocopherol and the shell is based on sugar-derived amphiphilic polymers that exhibit scavenger receptor binding and counteract atherogenesis.

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