Gadd45γregulates cardiomyocyte death and post-myocardial infarction left ventricular remodelling | Zendy

Alexandre Lucas | Zendy; Jeanne MialetPerez | Zendy; Danièle Daviaud | Zendy; Angelo Parini | Zendy; Michael Marber | Zendy; Pierre Sicard | Zendy

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Gadd45γregulates cardiomyocyte death and post-myocardial infarction left ventricular remodelling

Author(s) -

Alexandre Lucas,

Jeanne MialetPerez,

Danièle Daviaud,

Angelo Parini,

Michael Marber,

Pierre Sicard

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv219

Subject(s) - gadd45 , p38 mitogen activated protein kinases , microbiology and biotechnology , knockout mouse , mapk/erk pathway , apoptosis , biology , medicine , signal transduction , receptor , cell cycle , genetics , cell cycle checkpoint

Post-infarction remodelling is accompanied and influenced by perturbations in mitogen-activated protein kinase (MAPK) signalling. The growth arrest and DNA-damage-inducible 45 (Gadd45) proteins are small acidic proteins involved in DNA repair and modulation of MAPK activity. Little is known about the role of Gadd45 in the heart. Here, we explored the potential contribution of Gadd45 gamma (γ) isoform to the acute and late phase of heart failure (HF) after myocardial infarction (MI) and determined the mechanisms underlying Gadd45γ actions.

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