ALK7 protects against pathological cardiac hypertrophy in mice | Zendy

He Huang | Zendy; Yanhong Tang | Zendy; Gang Wu | Zendy; Mei Yang | Zendy; Wanli Liu | Zendy; Xiaoxiong Liu | Zendy; Nian Wan | Zendy; Yu Liu | Zendy; Congxin Huang | Zendy

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ALK7 protects against pathological cardiac hypertrophy in mice

Author(s) -

He Huang,

Yanhong Tang,

Gang Wu,

Mei Yang,

Wanli Liu,

Xiaoxiong Liu,

Nian Wan,

Yu Liu,

Congxin Huang

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv206

Subject(s) - muscle hypertrophy , pressure overload , pathological , cardiac function curve , angiotensin ii , medicine , knockout mouse , fibrosis , endocrinology , cardiac hypertrophy , genetically modified mouse , phenotype , cardioprotection , cardiology , transgene , heart failure , receptor , biology , myocardial infarction , biochemistry , gene

Activin receptor-like kinase 7 (ALK7), one of the type I transforming growth factor-β receptors, is expressed in various tissues, including the heart. However, the participation of ALK7 in the regulation of cardiac hypertrophy has not yet been studied. Here, we sought to determine the regulatory role and underlying mechanisms of ALK7 in cardiac hypertrophy.

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