Open AccessTWEAK/Fn14 interaction promotes oxidative stress through NADPH oxidase activation in macrophages
Author(s) -
Julio MadrigalMatute,
Valvanera FernándezLaso,
Cristina Sastre,
Patricia LlamasGranda,
Jesús Egido,
José Luis MartínVentura,
Guillermo Zalba,
Luis Miguel BlancoColio
Publication year - 2015
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvv204
Subject(s) - oxidative stress , nadph oxidase , chemistry , microbiology and biotechnology , oxidative phosphorylation , biochemistry , biology
The interaction between TNF-like weak inducer of apoptosis (TWEAK, Tnfsf12) and the receptor, fibroblast growth factor-inducible 14 (Fn14), regulates vascular damage through different mechanisms, including inflammation. Oxidative stress plays a major role in inflammation and the development of atherosclerosis, but the relationship between TWEAK and oxidative stress is, however, poorly understood.
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