Open AccessPlatelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis
Author(s) -
Christophe Vandenbriele,
Alexandre Kauskot,
Ine Vandersmissen,
Maarten Criel,
Rachel Geenens,
Sander Craps,
Aernout Luttun,
Stefan Janssens,
Marc Hoylaerts,
Peter Verhamme
Publication year - 2015
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvv193
Subject(s) - angiogenesis , matrigel , chemistry , cd31 , microvessel , pharmacology , protein kinase b , in vitro , neovascularization , in vivo , receptor , microbiology and biotechnology , biology , endocrinology , signal transduction , biochemistry , cancer research
Platelet endothelial aggregation receptor-1 (PEAR1) is a cell membrane protein, expressed on platelets and endothelial cells (ECs). PEAR1 sustains αIIbβ3 activation in aggregating platelets and attenuates megakaryopoiesis via controlling the degree of Akt phosphorylation. Its role in EC biology is unknown. The aim of this study was to determine the expression of PEAR1 in the human endothelium of various tissues and to investigate its role in ECs in vitro and in angiogenesis, using Pear1(-/-) mice.
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