Open AccessMembrane-bound Klotho is not expressed endogenously in healthy or uraemic human vascular tissue
Author(s) -
Rik Mencke,
Geert Harms,
Katarina Mirković,
Joyce A. Struik,
Joris van Ark,
Ellen Van Loon,
Melissa Verkaik,
Martin H. de Borst,
Clark J. Zeebregts,
Joost G.J. Hoenderop,
Marc Vervloet,
JanLuuk Hillebrands
Publication year - 2015
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvv187
Subject(s) - klotho , vascular tissue , medicine , vascular smooth muscle , endocrinology , biology , microbiology and biotechnology , kidney , smooth muscle , botany
Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD), a disease state that is strongly associated with loss of renal and systemic (alpha-)Klotho. Reversely, murine Klotho deficiency causes marked medial calcification. It is therefore thought that Klotho conveys a vasculoprotective effect. Klotho expression in the vessel wall, however, is disputed.
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