Citrullination of myofilament proteins in heart failure | Zendy

Justyna FertBober | Zendy; Jon T. Giles | Zendy; Ronald J. Holewinski | Zendy; Jonathan A. Kirk | Zendy; Helge Uhrigshardt | Zendy; Erin L. Crowgey | Zendy; Felipe Andrade | Zendy; Clifton O. Bingham | Zendy; Jin Kyun Park | Zendy; Marc K. Halushka | Zendy; David A. Kass | Zendy; Joan M. Bathon | Zendy; Jennifer E. Van Eyk | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Citrullination of myofilament proteins in heart failure

Author(s) -

Justyna FertBober,

Jon T. Giles,

Ronald J. Holewinski,

Jonathan A. Kirk,

Helge Uhrigshardt,

Erin L. Crowgey,

Felipe Andrade,

Clifton O. Bingham,

Jin Kyun Park,

Marc K. Halushka,

David A. Kass,

Joan M. Bathon,

Jennifer E. Van Eyk

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv185

Subject(s) - myofilament , heart failure , citrullination , medicine , cardiology , chemistry , biochemistry , myocyte , citrulline , arginine , amino acid

Citrullination, the post-translational conversion of arginine to citrulline by the enzyme family of peptidylarginine deiminases (PADs), is associated with several diseases, and specific citrullinated proteins have been shown to alter function while others act as auto-antigens. In this study, we identified citrullinated proteins in human myocardial samples, from healthy and heart failure patients, and determined several potential functional consequences. Further we investigated PAD isoform cell-specific expression in the heart.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research