Slit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle via reduced eNOS activity | Zendy

Tiiieminen | Zendy; Pyry I. Toivanen | Zendy; Johanna P. Laakkonen | Zendy; Tommi Heikura | Zendy; Minna U. Kaikkonen | Zendy; Kari J. Airenne | Zendy; Seppo YläHerttuala | Zendy

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Slit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle via reduced eNOS activity

Author(s) -

Tiiieminen,

Pyry I. Toivanen,

Johanna P. Laakkonen,

Tommi Heikura,

Minna U. Kaikkonen,

Kari J. Airenne,

Seppo YläHerttuala

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv161

Subject(s) - angiogenesis , vascular permeability , kinase insert domain receptor , biology , microbiology and biotechnology , vascular endothelial growth factor , vascular endothelial growth factor a , chemistry , endocrinology , cancer research , vegf receptors

Slit2 is a possible modulator of VEGF-induced angiogenesis, but its effects have not been tested on large animal models. We studied the effect of Slit2 on therapeutic angiogenesis induced by VEGF receptor 2 (VEGFR2) ligands Vammin and VEGF-D(ΔNΔC) in vivo in rabbit skeletal muscles. The Slit2 target genes were also studied by RNA sequencing in endothelial cells.

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