Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis | Zendy

Ralph Klose | Zendy; Caroline Berger | Zendy; Iris Moll | Zendy; Mohamed Adam | Zendy; Frank Schwarz | Zendy; Kerstin Möhr | Zendy; Hellmut G. Augustin | Zendy; Andreas Fischer | Zendy

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Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis

Author(s) -

Ralph Klose,

Caroline Berger,

Iris Moll,

Mohamed Adam,

Frank Schwarz,

Kerstin Möhr,

Hellmut G. Augustin,

Andreas Fischer

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv151

Subject(s) - notch signaling pathway , jag1 , angiogenesis , notch proteins , microbiology and biotechnology , notch 1 , biology , receptor , chemistry , sprouting angiogenesis , signal transduction , neovascularization , biochemistry , cancer research

Notch signalling is essential for blood vessel formation. During angiogenesis, the Notch ligand DLL4 on the leading tip cell activates Notch receptors on the adjacent stalk cells. DLL4-Notch signalling is impaired by the Notch ligand JAG1 in endothelial cells. The Delta/Serrate/Lag2 (DSL) domain of the Notch ligands binds to the EGF-like repeats 11-13 of the Notch receptor. This study aimed to elucidate how soluble proteins containing these short domains interfere with Notch signalling during angiogenesis.

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