Soluble VE-cadherin is involved in endothelial barrier breakdown in systemic inflammation and sepsis | Zendy

Sven Flemming | Zendy; Natalie Burkard | Zendy; Markus F. Renschler | Zendy; Franziska Vielmuth | Zendy; Michael Meir | Zendy; Martin A. Schick | Zendy; Christian Wunder | Zendy; ChristophThomas Germer | Zendy; Volker Spindler | Zendy; Jens Waschke | Zendy; Nicolas Schlegel | Zendy

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Soluble VE-cadherin is involved in endothelial barrier breakdown in systemic inflammation and sepsis

Author(s) -

Sven Flemming,

Natalie Burkard,

Markus F. Renschler,

Franziska Vielmuth,

Michael Meir,

Martin A. Schick,

Christian Wunder,

ChristophThomas Germer,

Volker Spindler,

Jens Waschke,

Nicolas Schlegel

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv144

Subject(s) - ve cadherin , cadherin , inflammation , endothelial stem cell , endothelium , endothelial activation , microbiology and biotechnology , biology , barrier function , adam10 , chemistry , immunology , metalloproteinase , cell , matrix metalloproteinase , disintegrin , in vitro , biochemistry , endocrinology

Microvascular endothelial barrier breakdown in sepsis precedes organ failure and death in patients. We tested the hypothesis that the formation of endothelium-derived soluble vascular endothelial (VE)-cadherin fragments (sVE-cadherin) is involved in inflammation-induced endothelial barrier disruption.

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