Interplay between troponin T phosphorylation and O-N-acetylglucosaminylation in ischaemic heart failure | Zendy

Emilie DuboisDeruy | Zendy; Aude Belliard | Zendy; Paul Mulder | Zendy; Marion Bouvet | Zendy; Caroline SmetNocca | Zendy; Sébastien Janel | Zendy; Frank Lafont | Zendy; Olivia Beseme | Zendy; Philippe Amouyel | Zendy; Vincent Richard | Zendy; F Pinet | Zendy

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Interplay between troponin T phosphorylation and O-N-acetylglucosaminylation in ischaemic heart failure

Author(s) -

Emilie DuboisDeruy,

Aude Belliard,

Paul Mulder,

Marion Bouvet,

Caroline SmetNocca,

Sébastien Janel,

Frank Lafont,

Olivia Beseme,

Philippe Amouyel,

Vincent Richard,

F Pinet

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv136

Subject(s) - phosphorylation , serine , medicine , endocrinology , protein kinase c , chemistry , heart failure , troponin t , biology , biochemistry , myocardial infarction

Previous studies have reported that decreased serine 208 phosphorylation of troponin T (TnTpSer208) is associated with ischaemic heart failure (HF), but the molecular mechanisms and functional consequences of these changes are unknown. The aim of this study was to characterize the balance between serine phosphorylation and O-N-acetylglucosaminylation (O-GlcNAcylation) of TnT in HF, its mechanisms, and the consequences of modulating these post-translational modifications.

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