Open AccessDeriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence
Author(s) -
Yonggang Ma,
Ying Ann Chiao,
Ryan Clark,
Elizabeth R. Flynn,
Andriy Yabluchanskiy,
Omid Ghasemi,
Fouad A. Zouein,
Merry L. Lindsey,
Yu-Fang Jin
Publication year - 2015
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvv128
Subject(s) - ageing , macrophage polarization , senescence , cardiac fibrosis , fibrosis , ventricle , medicine , inflammation , endocrinology , diastole , macrophage , biology , in vitro , genetics , blood pressure
Cardiac ageing involves the progressive development of cardiac fibrosis and diastolic dysfunction coordinated by MMP-9. Here, we report a cardiac ageing signature that encompasses macrophage pro-inflammatory signalling in the left ventricle (LV) and distinguishes biological from chronological ageing.
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