Open AccessDNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1
Author(s) -
Senad Medunjanin,
JanMarcus Daniel,
Sönke Weinert,
Jochen Dutzmann,
Frank Burgbacher,
Sarah Brecht,
Dennis Bruemmer,
Thilo Kähne,
Michael Naumann,
Daniel Sedding,
Werner Zuschratter,
Ruediger C. BraunDullaeus
Publication year - 2015
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvv126
Subject(s) - biology , nuclear receptor , vascular smooth muscle , microbiology and biotechnology , phosphorylation , neuron derived orphan receptor 1 , cell growth , protein kinase a , biochemistry , endocrinology , transcription factor , gene , smooth muscle
Being central part of the DNA repair machinery, DNA-dependent protein kinase (DNA-PK) seems to be involved in other signalling processes, as well. NOR1 is a member of the NR4A subfamily of nuclear receptors, which plays a central role in vascular smooth muscle cell (SMC) proliferation and in vascular proliferative processes. We determined putative phosphorylation sites of NDA-PK in NOR1 and hypothesized that the enzyme is able to modulate NOR1 signalling and, this way, proliferation of SMC.
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